ADRENALS, CORTISOL AND THE IMMUNE RESPONSE – PART 2
On the previous blog I wrote about how a deficient cortisol circadian curve may leave you susceptible to an increase in allergies, inflammation, autoimmune condition and recurrent colds. But what happens if your natural cortisol circadian rhythm is elevated and not suppressed? A specifically increase in cortisol (as when dosed with synthetic glucocorticoid such as prednisone) may be beneficial when we are sick, however, a constant elevation in cortisol also has immune implications. Chronic elevated cortisol has been found to produce a pro-inflammatory response consistent with the promotion of the development of diseases. This is one of the reasons I, persistently, recommend the cortisol saliva test. The information derived from this test helps guide treatment and draw attention to the real problem. You may be asking “so, what causes cortisol to become elevated?” and the answer is most likely stress. Chronic stress is a risk factor for disease because it increases the action of the glucocorticoid receptor (where cortisol binds) which is responsible for the regulation of metabolism, immune response and development. How do we address stress? Go back to the blogs where I discuss the importance of a solid foundation; this is where you should start.