Hashimoto’s and Thyroid Hormone

 In Blog

In a normal functioning thyroid gland, the thyroid receives a message to produce thyroid hormone from the pituitary gland and the normal cascade of hormone ensues. In Hashimoto’s, there are 3 different possible scenarios that can occur thus affecting the production, conversion or binding of thyroid hormone and therefore slowing down metabolic processes within the body.

NORMAL THYROID:

TSH (from the pituitary gland) —-> THYROID GLAND ——-> T4 and T3

The thyroid pumps out 90% T4 hormone and 10% of T3

T4 is converted into T3 by an enzyme called 5-deiodinase

T3 become unbound = FREE T3 and binds to thyroid receptors

 

HASHIMOTO’S THYROID SCENARIO 1:

TSH (from the pituitary gland) —-> THYROID GLAND ——-> AUTOIMMUNITY

–> An autoimmune response against thyroid peroxidase (TPO) and/or thyroglobulin (TG) occurs within the thyroid gland à this can impair the amount of T4 or T3 that gets released by the thyroid

 

HASHIMOTO’S THYROID SCENARIO 2:

TSH (from the pituitary gland) —-> THYROID GLAND ——-> AUTOIMMUNITY

–> An autoimmune response against thyroid peroxidase (TPO) and/or thyroglobulin (TG) occurs within the thyroid gland à this can impair the amount of T4 or T3 that gets released by the thyroid

–> There is also a down-regulation of the enzyme 5-deiodinase  which can impair the conversion of T4 to T3

 

HASHIMOTO’S THYROID SCENARIO 3:

TSH (from the pituitary gland) —-> THYROID GLAND ——-> AUTOIMMUNITY

–> An autoimmune response against thyroid peroxidase (TPO) and/or thyroglobulin (TG) occurs within the thyroid gland à this can impair the amount of T4 or T3 that gets released by the thyroid

–> The thyroid receptors are impaired and FT3 cannot bind thus affecting metabolic activity

 

 

 

Recommended Posts

Start typing and press Enter to search

Call Now
Get Directions